In 1997, Weng Kee Wong won the First Independent Research Support and Transition Award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. He participated in several rheumatoid arthritis (RA) studies, including "High versus Low Dose Pencillamine in Systemic Sclerosis" and "Long Term Observational Study of Early Severe RA Patients". Earlier on, he also served as the director of the "Multipurpose Arthritis Center Data Analysis Core" from 1995-1998. Currently, he is the biostatistician for the "Multi-Center Phase II Trial of Oral Type I Bovine Collagen in Scleroderma" supported by the National Institutes of Health (NIH). He has also participated in NIH-supported research work in dentistry and environment health science.

His general area of research is in optimal design of experiments with applications to clinical trials and non-linear models. He is particularly interested in the construction of multiple-objective designs. These designs are appealing because they are flexible and they capture the goals of the practitioners more accurately. His work is published in both theoretical and applied journals in statistics, including pharmaceutical sciences and theoretical biology.